Sergio Parisse is set to become Italy's most capped international after the captain was recalled for the November Tests against New Zealand, South Africa and Tonga.
Parisse sat out the Azzurri's tour of South and North America in June, but Connor O'Shea has included the number eight in a 30-man squad for the clashes with the world champions, the Springboks and Tonga.
The vastly experienced 33-year-old is level with Martin Castrogiovanni on 119 caps for his country, but barring injury he is set to top the list on his own next month.
Back-row forward Alessandro Zanni and hooker Leonardo Ghiraldini are also back in the fold, while uncapped scrum-half Giorgio Bronzini has been called up for the first time.
Head coach O'Shea, whose first home game in charge will be against the All Blacks at Stadio Olimpico on November 12, said: "Twenty of the 30 selected players played in the summer tour and that will give us solidity,
"But we'll also rediscover some big names who will give us energy.
"These are three big challenges awaiting us in November and we live for moments like these. I know this team has the right qualities to make Italian rugby proud."
Forwards: Pietro Ceccarelli, Lorenzo Cittadini, Simone Ferrari, Andrea Lovotti, Sami Panico, Ornel Gega, Leonardo Ghiraldini, George Fabio Biagi, Joshua Furno, Marco Fuser, Quintin Geldenhuys, Simone Favaro, Maxime Mata Mbanda, Francesco Minto, Sergio Parisse, Andries Van Schalkwyk, Alessandro Zanni
Backs: Giorgio Bronzini, Edoardo Gori, Marcello Violi, Tommaso Allan, Carlo Canna, Tommaso Benvenuti, Tommaso Boni, Andrea Buondonno, Michele Campagnaro, Angelo Esposito, Luke McLean, Edoardo Padovani, Leonardo Sarto.