Manu Tuilagi has been ruled out of England's forthcoming tour to Australia through injury.
The Leicester Tigers centre had been included in Eddie Jones' 32-man squad for the three Tests despite struggling with a hamstring problem picked up in the Premiership semi-finals.
However, following a scan on Monday, Tuilagi has now been advised to sit out the fixtures.
"It's bad luck for Manu so close to the tour but it provides a great opportunity for someone else," said head coach Eddie Jones. "We wish Manu all the best and a quick recovery."
A replacement for Tuilagi will not be named until after Sunday's clash with Wales at Twickenham.
England kick off their Australia series in Brisbane on June 11.