Paddy Jackson has been preferred to Ian Madigan at fly-half in the Ireland side to face South Africa in the first Test at Newlands on Saturday.
Ulster number 10 Jackson gets the nod to make his first start since last August in the absence of Jonathan Sexton, who was ruled out of the tour due to a shoulder injury.
Jared Payne switches from centre to full-back, with Joe Schmidt opting for Luke Marshall and Robbie Henshaw as his midfield pairing in Cape Town.
Andrew Trimble and Keith Earls will start on the wings in a side which will once again be captained by Rory Best.
South Africa-born flanker CJ Stander will play against his country of birth for the first time, with lock Iain Henderson and flanker Jordi Murphy added to the pack for the opening game of the three-match series.
Uncapped scrum-half Faf de Klerk was named in the Springboks' starting XV for the first Test on Thursday at the start of a new era under head coach Allister Coetzee.
Ireland: Jared Payne, Andrew Trimble, Robbie Henshaw, Luke Marshall, Keith Earls, Paddy Jackson, Conor Murray; Jack McGrath, Rory Best, Mike Ross, Iain Henderson, Devin Toner, CJ Stander, Jordi Murphy, Jamie Heaslip.
Replacements: Sean Cronin, Finlay Bealham, Tadhg Furlong, Ultan Dillane, Rhys Ruddock, Kieran Marmion, Ian Madigan, Craig Gilroy.