Eben Etzebeth will miss South Africa's Test against Italy on Saturday after suffering concussion in the defeat to England.
The giant lock was withdrawn in the first half of last weekend's 37-21 defeat at Twickenham after he came off worse in a clash of heads with Billy Vunipola when he tried to bring down the charging England number eight.
Springboks head coach Allister Coetzee revealed that Etzebeth's injury did not look good following his side's loss to Eddie Jones' men.
And Coetzee confirmed on Monday that the forward will not feature at Stadio Artemio Franchi this weekend.
There is positive news of wing Bryan Habana, who is set to return in Florence after missing the loss to England due to a knee injury.