Sharks scrum-half Cobus Reinach has been ruled out for nine months with a knee ligament injury as team-mate Pat Lambie prepares to make his comeback.
Playmaker Reinach returned early from Sharks' tour of New Zealand after damaging his knee in the 15-14 Super Rugby victory at Highlanders last month.
Sharks revealed on Tuesday the 26-year-old requires surgery and is set for a long spell on the sidelines.
There is more positive news over fly-half Pat Lambie, who is set to return from a shoulder injury against Hurricanes on Saturday.
Lambie has not featured this season due to an injury sustained during a pre-season tour of France, but has been passed fit to face last year's runners-up at Kings Park.
Philip van der Walt is expected to be out for two to three weeks with a neck injury.
Sharks occupy fourth spot in the South African Group and second in Africa 2 after going down 24-22 at Chiefs last Friday in the final game of their tour.