Guglielmo Palazzani and Edoardo Padovani will form a new half-back pairing when Italy face Ireland in the Six Nations on Saturday.
Italy head coach Jacques Brunel makes four changes to the side which was beaten by Scotland in Rome.
Palazzani replaces the injured Edoardo Gori at scrum-half, while Padovani gets the nod over Kelly Haimona at fly-half in Dublin.
Captain Leonardo Ghiraldini will not feature due to a shoulder injury, so Davide Giazzon starts as hooker and George Biagi makes a timely return to the second row in the absence of the injured Josh Furno.
Hooker Oliviero Fabiani and scrum-half Alberto Lucchese are poised to make their international debuts from the bench in a match between two sides still eyeing a first win of the tournament.
Sergio Parisse takes over as captain in the absence of Ghiraldini, while Martin Castrogiovanni will not feature at the Aviva Stadium after the veteran prop was banned for a stamp on Scotland's Duncan Taylor.
Italy team to face Ireland: David Odiete, Leonardo Sarto, Michele Campagnaro, Gonzalo Garcia, Mattia Bellini, Edoardo Padovani, Guglielmo Palazzani; Andrea Lovotti, Davide Giazzon, Lorenzo Cittadini, George Biagi, Marco Fuser, Francesco Minto, Alessandro Zanni, Sergio Parisse
Replacements: Oliviero Fabiani, Matteo Zanusso, Dario Chistolini, Quintin Geldenhuys, Abraham Steyn, Alberto Lucchese, Kelly Haimona, Luke Mclean