Veteran prop Martin Castrogiovanni will face Wales as one of five changes to Jacques Brunel's starting XV for his final game in charge of Italy.
Brunel will step down following the Six Nations and take up a role as Bordeaux-Begles' forwards coach.
And Castrogiovanni, whose record haul of 118 Italy caps was equalled by skipper Sergio Parisse last weekend, returns from a two-week suspension to take his place in the front row for Saturday's game in Cardiff.
Italy, who are already certain to pick up the wooden spoon, have also recalled fly-half Tommaso Allan, centre Andrea Pratichetti and locks Quintin Geldenhuys and Valerio Bernabo as they deal with an increasingly lengthy injury list. Zebre flanker Jacopo Sarto could make his debut from the bench.
Italy team to face Wales: David Odiete, Leonardo Sarto, Andrea Pratichetti, Gonzalo Garcia, Mattia Bellini, Tommaso Allan, Guglielmo Palazzani; Andrea Lovotti, Davide Giazzon, Martin Castrogiovanni, Quintin Geldenhuys, Valerio Bernabo, Francesco Minto, Alessandro Zanni, Sergio Parisse (captain).
Replacements: Oliviero Fabiani, Matteo Zanusso, Dario Chistolini, Jacopo Sarto, Abraham Steyn, Alberto Lucchese, Kelly Haimona, Luke McLean.